基本信息：

姓名：黄园园

性别：女

出生年月：1991年6月

最终学历（学位）：博士研究生

职称：讲师（硕士生导师）

联系方式：huangyy@hpu.edu.cn

教育及工作经历：

2023.08-至今：伟德国际BETVlCTOR，伟德betvlctor国际官网，讲师

2021.03-2023.08：中国科学院苏州纳米技术与纳米仿生研究所，博士后

2017.09-2020.12：南京大学，化学专业，理学博士

2014.09-2017.06：浙江师范大学，化学专业，理学硕士

2010.09-2014.06：嘉兴学院，应用化学专业，工学学士

科研领域及主要科研成果：

主要从事发光金属纳米簇及其复合材料在分析检测、细胞成像、癌症治疗及发光器件等方面的应用研究。主持国家自然科学基金青年基金项目1项、中国博士后科学基金会-面上项目1项，江苏省博士后科研资助计划1项，参与国家级面上项目2项。入选2022年江苏省“双创博士”。发表SCI论文近20篇（其中第一作者论文8篇），发明专利1项。

科研项目：

1. 国家自然科学基金-青年科学基金项目：双模态自我治疗型近红外二区发光金-铜双金属纳米簇的构建及其用于级联化学/化学动力学癌症精准治疗研究，30万元，主持，2023-2025。

2. 中国博士后科学基金会-面上项目：双模态自我治疗型铜纳米簇的构建及其用于荧光成像指导的级联化学/化学动力学癌症精准治疗，8万元，主持，2021-2023。

3. 江苏省博士后科研资助计划：肿瘤微环境激活的“智能”功能化铜纳米簇用于特定生物酶的荧光示踪分析，2万元，2021-2023，主持。

4. 浙江师范大学“化学”重中之重学科研究生创新训练项目：基于碳量子点的功能高分子修饰及其应用，1万元，2015-2016，主持。

5. 国家自然科学基金委员会-面上项目：聚集诱导发光的金属纳米簇的可控制备、机制探讨和生物传感应用，65万元，2018-2021，参与。

6. 国家自然科学基金委员会-面上项目：功能化碳量子点荧光纳米开关的设计、构建及在生物酶检测中的应用，65万元，2017-2020，参与。

发表论文：

1. Yuanyuan Huang,^† Jianya Zhang,^† Min Zhou, Renjun Pei^* and Yukun Zhao^*. Engineering GaN/AuNC Core-Shell Nanowire Heterojunction by Gold Nanoclusters with Excitation-Dependent Behavior to Enhance the Responsivity and Stability of Self-Driven Photodetector. Nanoscale Advances, 2023, DOI:10.1039/d3na00463e.

2. Yuanyuan Huang,^† Longyi Zhu,^† Jiahao Ji, Yang Li, Tianrui Liu, and Jianping Lei^*. Cleancap-Regulated Aggregation-Induced Emission Strategy for Highly Specific Analysis of Enzyme. Analytical Chemistry, 2020, 92, 4726-4730.

3. Yuanyuan Huang, Jing Huang, Yikun Wang, Fengjiao Ma, Jiahao Ji, Jianping Lei^*. Progressive Aggregation-Induced Emission Strategy for Imaging of Aluminum Ions in Cellular Microenvironment. Talanta, 2020, 211, 120699.

4. Yuanyuan Huang, Jiahao Ji, Jing Zhang,^* Fang Wang and Jianping Lei^*. Host-Guest Recognition-Regulated Aggregation-Induced Emission for in Situ Imaging of MUC1 Protein. Chemical Communications, 2020, 56, 313-316.

5.  Yuanyuan Huang,^† Hui Feng,^† Weidong Liu,^† Shasha Zhang, Cong Tang, Jianrong Chen and Zhaosheng Qian^*. Cation-Driven Luminescent Self-Assembled Dots of Copper Nanoclusters with Aggregation-Induced Emission for β-Galactosidase Activity Monitoring. Journal of Materials Chemistry B, 2017, 5, 5120-5127.

6. Yuanyuan Huang,^† Jin Zhou,^† Hui Feng, Jieyu Zheng, Hui-Min Ma, Weidong Liu, Cong Tang, Hang Ao, Meizhi Zhao, Zhaosheng Qian^*. Cation-Driven Luminescent Self-Assembled Dots of Copper Nanoclusters with Aggregation-Induced Emission for β-Galactosidase Activity Monitoring. Biosensors and Bioelectronics, 2016, 86, 748-755.

7. Yuanyuan Huang,^† Hui Feng,^† Weidong Liu, Yingying Zhou, Cong Tang, Hang Ao, Meizhi Zhao, Guilin Chen, Jianrong Chen, and Zhaosheng Qian^*. Luminescent Aggregated Copper Nanoclusters Nanoswitch Controlled by Hydrophobic Interaction for Real-Time Monitoring of Acid Phosphatase Activity. Analytical Chemistry, 2016, 88, 7429-7434.

8. Yuanyuan Huang,^† Weidong Liu,^† Hui Feng, Yangting Ye, Cong Tang, Hang Ao, Meizhi Zhao, Guilin Chen, Jianrong Chen, and Zhaosheng Qian^*. Luminescent Nanoswitch Based on Organic-Phase Copper Nanoclusters for Sensitive Detection of Trace Amount of Water in Organic Solvents. Analytical Chemistry, 2016, 88, 7429-7434.

9. Cong Tang,^† Hui Feng,^† Yuanyuan Huang, Zhaosheng Qian^*. Reversible Luminescent Nanoswitches Based on Aggregation-Induced Emission Enhancement of Silver nanoclusters for Luminescence Turn-on Assay of Inorganic Pyrophosphatase Activity. Analytical Chemistry, 2017, 89, 4994-5002.

10. Cong Tang, Zhaosheng Qian, Yuanyuan Huang, Jiamin Xu, Hang Ao, Meizhi Zhao, Jin Zhou, Jianrong Chen, Hui Feng^*. A Fluorometric Assay for Alkaline Phosphatase Activity Based on Beta-Cyclodextrin-Modified Carbon Quantum Dots Through Host-Guest Recognition. Biosensors and Bioelectronics, 2016, 83, 274-280.

11. Zhaosheng Qian, Lujing Chai, Yuanyuan Huang, Cong Tang, Jiajia Shen, Jianrong Chen, Hui Feng*. A Real-Time Fluorescent Assay for The Detection of Alkaline Phosphatase Activity Based on Carbon Quantum Dots. Biosensors and Bioelectronics, 2015, 68, 675-680.

12. Cong Tang,^† Zhaosheng Qian,^† Yinjie Qian, Yuanyuan Huang, Meizhi Zhao, Hang Ao, Hui Feng^*. A Fluorometric and Real-time Assay for α-Glucosidase Activity Through Supramolecular Self-assembly and Its Application for Inhibitor Screening. Sensors and Actuators B: Chemical, 2017, 245, 282-289.

13. Zhaosheng Qian, Lujing Chai, Cong Tang, Yuanyuan Huang, Jianrong Chen, Hui Feng*. A Fluorometric Assay for Acetylcholinesterase Activity and Inhibitor Screening with Carbon Quantum Dots. Sensors and Actuators B: Chemical, 2016, 222, 879-886.

14. Zhaosheng Qian, Lujing Chai, Cong Tang, Yuanyuan Huang, Jianrong Chen, Hui Feng^*. Carbon Quantum Dots-Based Recyclable Real-Time Fluorescence Assay for Alkaline Phosphatase with Adenosine Triphosphate asSubstrate. Analytical Chemistry, 2015, 87, 2966−2973. 

15. Zhaosheng Qian, Lujing Chai, Qian Zhou, Yuanyuan Huang, Cong Tang, Jianrong Chen, and Hui Feng^*. Reversible Fluorescent Nanoswitch Based on Carbon Quantum DotsNanoassembly for Real-Time Acid Phosphatase Activity Monitoring. Analytical Chemistry, 2015, 87, 7332−7339.

16. Jiarui Yang, Pengfei Dong, Yikun Wang*, Tianrui Liu, Yuanyuan Huang, Jianping Lei^*. Stepwise Recognition Strategy for Detection of Telomerase Activity via Direct Electrochemistry of Metal–Organic Frameworks. Analyst, 2021,146, 1859-1864.

17. Cong Tang,^† Jin Zhou,^† Zhaosheng Qian^†, Yanyan Ma, Yuanyuan Huang, Hui Feng^*. A Universal Fluorometric Assay Strategy for Glycosidases Based on Functional Carbon Quantum Dots: ß-Galactosidase Activity Detection in vitro and in Living Cells. Journal of Materials Chemistry B, 2017, 5, 1971-1979.

18. Lujing Chai, Jin Zhou, Hui Feng, Cong Tang, Yuanyuan Huang, Zhaosheng Qian^*. Functionalized Carbon Quantum Dots with Dopamine for TyrosinaseActivity Monitoring and Inhibitor Screening: In Vitro and Intracellular Investigation. ACS Applied Materials Interfaces, 2015, 7, 23564−23574.

19. Hang Ao, ^† Zhaosheng Qian,^† Yuyu Zhu, Meizhi Zhao, Cong Tang, Yuanyuan Huang, Hui Feng^*, Aijun Wang^*. A Fluorometric Biosensor Based on Functional Au/Ag Nanoclusters for Real-Time Monitoring of Tyrosinase Activity. Biosensors and Bioelectronics, 2016, 83, 542-547.

发明专利：

1.裴仁军，黄园园. 具有多重刺激响应性的金纳米簇聚集体及其制法与应用: 中国, 202310609090.3, 受理，申请日：2023-05-26.